huntington's disease research project

The Human Biology Project was launched in 2013 with the goal of fostering innovative research in collaboration with HD clinics to better understand the biology of Huntington's disease as it occurs in humans. HDSA encourages researchers to consider one of HDSA's Centers of Excellence as a potential collaborator, but applicants may propose to ...

New York, NY, December 4th, 2023 — Today, the Huntington's Disease Society of America (HDSA) announced that six research grants have been awarded under the Society's largest research initiative, the HDSA Huntington's Disease Human Biology Project. These grants represent HDSA's patient-centric research focus which brings basic and ...

Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. Our research efforts have helped to increase the number of scientists working on HD and have shed light on many of the complex biological mechanisms involved.

The Huntington's Disease Society of America (HDSA) has awarded $898,194 in funding to support six research projects aiming to better understand and find more effective treatments for Huntington's disease (HD). Grants were awarded through the HD Human Biology Project, HDSA's largest research initiative supporting work focused on how ...

What do we know about heredity and Huntington's disease? Huntington's disease (HD) is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline. In the United States alone, about 30,000 people have HD. In addition, 35,000 people exhibit some symptoms and 75,000 people carry the abnormal ...

Huntington's disease (HD) is a neurodegenerative condition with a wide neuropsychiatric clinical spectrum that may involve different combinations of movement disorders (primarily chorea), dementia, and behavioral or psychiatric manifestations. 1 HD is a polyglutamine disease caused by a CAG trinucleotide repeat expansion in the huntingtin gene (HTT), located on chromosome 4.

Keywords: chorea, antipsychotic medication, antidepressants, mood stabilizers, antisense oligonucleotides, RNAi therapies, Huntington's disease. HD is an autosomal dominant neurodegenerative disease that currently has no approved cure. HD is characterized by an increased number of CAG trinucleotide repeats in the huntingtin gene () on the ...

As a result, the Huntington's Disease Society of America has adopted a patient-centric research strategy to push the field closer to meeting our goal of identifying effective therapies. The Human Biology Project was launched in 2013 with the goal of fostering innovative research in collaboration with HD clinics to better understand the ...

Project Title: Discovery of therapeutic targets that can ameliorate Huntington's disease. Recent research in Huntington's disease focuses on how certain proteins interact and influence the disease. A key discovery is the role of a protein that interacts with another involved in DNA repair.

Huntington's disease (HD) is an autosomal dominantly-inherited neurodegenerative disease, which is caused by CAG trinucleotide expansion in exon 1 of the Huntingtin (HTT) gene. Although HD is a rare disease, its monogenic nature makes it an ideal model in which to understand pathogenic mechanisms and to develop therapeutic strategies for ...

Huntington's disease (HD) is a neurodegenerative disorder characterized by severe motor, cognitive and psychiatric symptoms. ... Entrepreneurship and Innovation, under the call RESEARCH-CREATE-INNOVATE (project code: T2EDK-02222); iii) 'INSPIRED-The National Research Infrastructures on Integrated Structural Biology, Drug Screening Efforts and ...

Tamara Maiuri is a Research Associate in Dr. Ray Truant's group at McMaster University, Canada. Prior to joining the Huntington's disease field, Tamara obtained her PhD from the Medical Biophysics Department at the University of Toronto where she studied the cell biology of cancer-related genes.

Sharon Sha, MD, MS Director, Huntington's Disease Center of Excellence Clinical Professor, Neurology & Neurological Sciences. Dr. Sharon Sha is a Clinical Professor at Stanford University. In addition to LBD RCOE Co-Director, she is Associate Vice Chair of Clinical Research for the Department of Neurology, Director of the Huntington's disease and Ataxia Clinic, clinical core co-leader of the ...

Huntington's Disease in Venezuela. View fullsize. In 1979, the U.S.-Venezuela Collaborative Research Project, a team of top international doctors and scientists, took the first of many trips to rural fishing villages along the shores of Lake Maracaibo in the state of Zulia, Venezuela. These villages have the highest concentration of Huntington ...

(A) Members of the Huntington's Disease Collaborative Research Group (HD‐CRG), taken at a workshop in Islamorada in the late 1980s (kindly supplied by Professor G Bates). (B) The discovery of the gene for HD has led to multiple potential disease‐modifying targets, such as targeting DNA repair proteins with the aim of reducing CAG expansion in the brain, and strategies to reduce levels of ...

Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. Our research efforts have helped to increase the number of scientists working on HD and have shed light on many of the complex biological mechanisms involved.

The disease typically progresses in four stages: prodromal stage, early-stage, moderate stage, and advanced-stage Huntington's disease. Progression between the stages is often slow and may take years or even decades, depending on the severity. Research on the disease has been ongoing since the discovery of the gene responsible.

The earliest extended description of Huntington's disease was described by physician George Huntington in 1872 in patients who presented with abnormal movements, dementia, and suicidal tendencies, which worsened throughout the years. ... The findings of the U.S-Venezuela Collaborative Research Project were critical in localizing a DNA marker ...

Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. Our research efforts have helped to increase the number of scientists working on HD and have shed light on many of the complex biological mechanisms involved.

Between 1981 and 2002, the U.S.-Venezuela Huntington's Disease Collaborative Research Group would amass 4,000 DNA samples and a genetic pedigree of over 18,000 people (with and without Huntington's), stretching back more than 10 generations over two centuries. They performed hundreds of annual cognitive and neurological assessments.

Fellows: The HD Human Biology Project Fellowships are provided as "seed monies" (up to $90,000 per year for up to two years) for new clinical or translational research projects that are directly related to understanding Huntington's disease in the hope that the results can be used to attract funding from other sources.

This study presents the clinical features and disease progression of a 39-year-old male patient diagnosed with Huntington's disease (HD). The diagnosis was confirmed by direct genetic testing, using DNA obtained from a blood sample that revealed expanded cytosine-adenine-guanine (CAG) repeats in the huntingtin gene (HD gene).

A researcher from the University of the Free State (UFS) is investigating the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases.The work of Dr Matlakala Claudia Ntsapi, Senior Lecturer in the Department of Basic Medical Sciences at the UFS, focuses on preserving human brain health ...

Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. Our research efforts have helped to increase the number of scientists working on HD and have shed light on many of the complex biological mechanisms involved.