science technology and society research paper

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

• View all journals

Science, technology and society articles from across Nature Portfolio

Latest research and reviews.

More than news! Mapping the deliberative potential of a political online ecosystem with digital trace data

• Lisa Oswald

Anticompetitive effect of drug name trademark registration: lessons from China

• Xiaoting Song

Urban traffic-parking system dynamics model with macroscopic properties: a comparative study between Shanghai and Zurich

• Biruk Gebremedhin Mesfin

Unveiling the origins of non-performance-oriented behavior in China’s local governments: a game theory perspective on the performance-based promotion system

• Huping Shang
• Hongmei Liu

An STS analysis of a digital humanities collaboration: trading zones, boundary objects, and interactional expertise in the DECRYPT project

• Benedek Láng
• Beáta Megyesi

Exploration of the creative processes in animals, robots, and AI: who holds the authorship?

• Cédric Sueur
• Jessica Lombard

News and Comment

Paris suv policy and urban sustainability.

• Zaheer Allam

Dangers of speech technology for workplace diversity

Speech technology offers many applications to enhance employee productivity and efficiency. Yet new dangers arise for marginalized groups, potentially jeopardizing organizational efforts to promote workplace diversity. Our analysis delves into three critical risks of speech technology and offers guidance for mitigating these risks responsibly.

• Mike Horia Mihail Teodorescu
• Mingang K. Geiger

Safeguarding young users on social media through academic oversight

The EU commission’s Digital Services Act aims to protect children and adolescents from psychological harm on social media platforms. This initiative needs to be carried out in close cooperation between the EU commission and independent academics.

• Christian Montag
• Peter J. Schulz
• Benjamin Becker

Hybrid intelligence for reconciling biodiversity and productivity in agriculture

Hybrid intelligence — arising from the sensible, targeted fusion of human minds and cutting-edge computational systems — holds great potential for enhancing the sustainability of agriculture. Leveraging the combined strengths of both collective human and artificial intelligence helps identify and stress-test pathways towards the reconciliation of biodiversity and productivity.

How to transition from academia to industry and back

Researchers have a wide variety of choices when it comes to careers. Often, post-PhD, we leave academic research for industry. But it is also possible to transition back, when done carefully. In this how-to, I outline how to transition between industry and academic research and vice versa.

• Cassandra L. Jacobs

Virtual reality for nature experiences

Given the increasing sophistication of virtual reality systems in providing immersive nature experiences, there is the potential for analogous health benefits to those that arise from real nature experiences. We call for research to better understand the human–nature–technology interaction to overcome potential pitfalls of the technology and design tailored virtual experiences that can deliver health outcomes and wellbeing across society.

• Violeta Berdejo-Espinola
• Renee Zahnow
• Richard A. Fuller

Quick links

• Explore articles by subject
• Guide to authors
• Editorial policies

Advertisement

Data science: a game changer for science and innovation

• Regular Paper
• Open access
• Published: 19 April 2021
• Volume 11 , pages 263–278, ( 2021 )

Cite this article

You have full access to this open access article

• Valerio Grossi 1 ,
• Fosca Giannotti 1 ,
• Dino Pedreschi 2 ,
• Paolo Manghi 3 ,
• Pasquale Pagano 3 &
• Massimiliano Assante 3  

14k Accesses

19 Citations

57 Altmetric

Explore all metrics

This paper shows data science’s potential for disruptive innovation in science, industry, policy, and people’s lives. We present how data science impacts science and society at large in the coming years, including ethical problems in managing human behavior data and considering the quantitative expectations of data science economic impact. We introduce concepts such as open science and e-infrastructure as useful tools for supporting ethical data science and training new generations of data scientists. Finally, this work outlines SoBigData Research Infrastructure as an easy-to-access platform for executing complex data science processes. The services proposed by SoBigData are aimed at using data science to understand the complexity of our contemporary, globally interconnected society.

Similar content being viewed by others

What Is Data Science?

Introduction to applied data science, data science.

Avoid common mistakes on your manuscript.

1 Introduction: from data to knowledge

Data science is an interdisciplinary and pervasive paradigm where different theories and models are combined to transform data into knowledge (and value). Experiments and analyses over massive datasets are functional not only to the validation of existing theories and models but also to the data-driven discovery of patterns emerging from data, which can help scientists in the design of better theories and models, yielding a deeper understanding of the complexity of the social, economic, biological, technological, cultural, and natural phenomenon. The products of data science are the result of re-interpreting available data for analysis goals that differ from the original reasons motivating data collection. All these aspects are producing a change in the scientific method, in research and in the way our society makes decisions [ 2 ].

Data science emerges to concurring facts: (i) the advent of big data that provides the critical mass of actual examples to learn from, (ii) the advances in data analysis and learning techniques that can produce predictive models and behavioral patterns from big data, and (iii) the advances in high-performance computing infrastructures that make it possible to ingest and manage big data and perform complex analysis [ 16 ].

Paper organization Section 2 discusses how data science impacts our science and society at large in the coming years. Section 3 outlines the main issues related to the ethical problems in studying human behaviors that data science introduces. In Sect.  4 , we show how concepts such as open science and e-infrastructure are effective tools for supporting, disseminating ethical uses of the data, and training new generations of data scientists. We will illustrate the importance of an open data science with examples provided later in the paper. Finally, we show some use cases of data science through thematic environments that bind the datasets with social mining methods.

2 Data science for society, science, industry and business

Data science as an ecosystem: on the left, the figure shows the main components enabling data science (data, analytical methods, and infrastructures). On the right, we can find the impact of data science into society, science, and business. All the activities related to data science should be done under rigid ethical principles

The quality of business decision making, government administration, and scientific research can potentially be improved by analyzing data. Data science offers important insights into many complicated issues, in many instances, with remarkable accuracy and timeliness.

The data science pipeline starts with raw data and transforms them into data used for analytics. The next step is to transform these data into knowledge through analytical methods and then provide results and evaluation measures

As shown in Fig.  1 , data science is an ecosystem where the following scientific, technological, and socioeconomic factors interact:

Data Availability of data and access to data sources;

Analytics & computing infrastructures Availability of high performance analytical processing and open-source analytics;

Skills Availability of highly and rightly skilled data scientists and engineers;

Ethical & legal aspects Availability of regulatory environments for data ownership and usage, data protection and privacy, security, liability, cybercrime, and intellectual property rights;

Applications Business and market ready applications;

Social aspects Focus on major societal global challenges.

Data science envisioned as the intersection between data mining, big data analytics, artificial intelligence, statistical modeling, and complex systems is capable of monitoring data quality and analytical processes results transparently. If we want data science to face the global challenges and become a determinant factor of sustainable development, it is necessary to push towards an open global ecosystem for science, industrial, and societal innovation [ 48 ]. We need to build an ecosystem of socioeconomic activities, where each new idea, product, and service create opportunities for further purposes, and products. An open data strategy, innovation, interoperability, and suitable intellectual property rights can catalyze such an ecosystem and boost economic growth and sustainable development. This strategy also requires a “networked thinking” and a participatory, inclusive approach.

Data are relevant in almost all the scientific disciplines, and a data-dominated science could lead to the solution of problems currently considered hard or impossible to tackle. It is impossible to cover all the scientific sectors where a data-driven revolution is ongoing; here, we shall only provide just a few examples.

The Sloan Digital Sky Survey Footnote 1 has become a central resource for astronomers over the world. Astronomy is being transformed from the one where taking pictures of the sky was a large part of an astronomer’s job, to the one where the images are already in a database, and the astronomer’s task is to find interesting objects and phenomenon in the database. In biological sciences, data are stored in public repositories. There is an entire discipline of bioinformatics that is devoted to the analysis of such data. Footnote 2 Data-centric approaches based on personal behaviors can also support medical applications analyzing data at both human behavior levels and lower molecular ones. For example, integrating genome data of medical reactions with the habits of the users, enabling a computational drug science for high-precision personalized medicine. In humans, as in other organisms, most cellular components exert their functions through interactions with other cellular components. The totality of these interactions (representing the human “interactome”) is a network with hundreds of thousand nodes and a much larger number of links. A disease is rarely a consequence of an abnormality in a single gene. Instead, the disease phenotype is a reflection of various pathological processes that interact in a complex network. Network-based approaches can have multiple biological and clinical applications, especially in revealing the mechanisms behind complex diseases [ 6 ].

Now, we illustrate the typical data science pipeline [ 50 ]. People, machines, systems, factories, organizations, communities, and societies produce data. Data are collected in every aspect of our life, when: we submit a tax declaration; a customer orders an item online; a social media user posts a comment; a X-ray machine is used to take a picture; a traveler sends a review on a restaurant; a sensor in a supply chain sends an alert; or a scientist conducts an experiment. This huge and heterogeneous quantity of data needs to be extracted, loaded, understood, transformed, and in many cases, anonymized before they may be used for analysis. Analysis results include routines, automated decisions, predictions, and recommendations, and outcomes that need to be interpreted to produce actions and feedback. Furthermore, this scenario must also consider ethical problems in managing social data. Figure 2 depicts the data science pipeline. Footnote 3 Ethical aspects are important in the application of data science in several sectors, and they are addressed in Sect.  3 .

2.1 Impact on society

Data science is an opportunity for improving our society and boosting social progress. It can support policymaking; it offers novel ways to produce high-quality and high-precision statistical information and empower citizens with self-awareness tools. Furthermore, it can help to promote ethical uses of big data.

Modern cities are perfect environments densely traversed by large data flows. Using traffic monitoring systems, environmental sensors, GPS individual traces, and social information, we can organize cities as a collective sharing of resources that need to be optimized, continuously monitored, and promptly adjusted when needed. It is easy to understand the potentiality of data science by introducing terms such as urban planning , public transportation , reduction of energy consumption , ecological sustainability, safety , and management of mass events. These terms represent only the front line of topics that can benefit from the awareness that big data might provide to the city stakeholders [ 22 , 27 , 29 ]. Several methods allowing human mobility analysis and prediction are available in the literature: MyWay [ 47 ] exploits individual systematic behaviors to predict future human movements by combining individual and collective learned models. Carpooling [ 22 ] is based on mobility data from travelers in a given territory and constructs a network of potential carpooling users, by exploiting topological properties, highlighting sub-populations with higher chances to create a carpooling community and the propensity of users to be either drivers or passengers in a shared car. Event attendance prediction [ 13 ] analyzes users’ call habits and classifies people into behavioral categories, dividing them among residents, commuters, and visitors and allows to observe the variety of behaviors of city users and the attendance in big events in cities.

Electric mobility is expected to gain importance for the world. The impact of a complete switch to electric mobility is still under investigation, and what appears to be critical is the intensity of flows due to charge (and fast recharge) systems that may challenge the stability of the power network. To avoid instabilities regarding the charging infrastructure, an accurate prediction of power flows associated with mobility is needed. The use of personal mobility data can estimate the mobility flow and simulate the impact of different charging behavioral patterns to predict power flows and optimize the position of the charging infrastructures [ 25 , 49 ]. Lorini et al. [ 26 ] is an example of an urban flood prediction that integrates data provided by CEM system Footnote 4 and Twitter data. Twitter data are processed using massive multilingual approaches for classification. The model is a supervised model which requires a careful data collection and validation of ground truth about confirmed floods from multiple sources.

Another example of data science for society can be found in the development of applications with functions aimed directly at the individual. In this context, concepts such as personal data stores and personal data analytics are aimed at implementing a new deal on personal data, providing a user-centric view where data are collected, integrated and analyzed at the individual level, and providing the user with better awareness of own behavioral, health, and consumer profiles. Within this user-centric perspective, there is room for an even broader market of business applications, such as high-precision real-time targeted marketing, e.g., self-organizing decision making to preserve desired global properties, and sustainability of the transportation or the healthcare system. Such contexts emphasize two essential aspects of data science: the need for creativeness to exploit and combine the several data sources in novel ways and the need to give awareness and control of the personal data to the users that generate them, to sustain a transparent, trust-based, crowd-sourced data ecosystem [ 19 ].

The impact of online social networks in our society has changed the mechanisms behind information spreading and news production. The transformation of media ecosystems and news consumption are having consequences in several fields. A relevant example is the impact of misinformation on society, as for the Brexit referendum when the massive diffusion of fake news has been considered one of the most relevant factors of the outcome of this political event. Examples of achievements are provided by the results regarding the influence of external news media on polarization in online social networks. These achievements indicate that users are highly polarized towards news sources, i.e., they cite (and tend to cite) sources that they identify as ideologically similar to them. Other results regard echo chambers and the role of social media users: there is a strong correlation between the orientation of the content produced and consumed. In other words, an opinion “echoes” back to the user when others are sharing it in the “chamber” (i.e., the social network around the user) [ 36 ]. Other results worth mentioning regard efforts devoted to uncovering spam and bot activities in stock microblogs on Twitter: taking inspiration from biological DNA, the idea is to model the online users’ behavior through strings of characters representing sequences of online users’ actions. As a result of the following papers, [ 11 , 12 ] report that 71% of suspicious users were classified as bots; furthermore, 37% of them also got suspended by Twitter few months after our investigation. Several approaches can be found in the literature. However, they generally display some limitations. Some of them work only on some of the features of the diffusion of misinformation (bot detections, segregation of users due to their opinions or other social analysis), or there is a lack of comprehensive frameworks for interpreting results. While the former case is somehow due to the innovation of the research field and it is explainable, the latter showcases a more fundamental need, as, without strict statistical validation, it is hard to state which are the crucial elements that permit a well-grounded description of a system. For avoiding fake news diffusion, we can state that building a comprehensive fake news dataset providing all information about publishers, shared contents, and the engagements of users over space and time, together with their profile stories, can help the development of innovative and effective learning models. Both unsupervised and supervised methods will work together to identify misleading information. Multidisciplinary teams made up of journalists, linguists, and behavioral scientists and similar will be needed to identify what amounts to information warfare campaigns. Cyberwarfare and information warfare will be two of the biggest threats the world will face in the 21st Century.

Social sensing methods collect data produced by digital citizens, by either opportunistic or participatory crowd-sensing, depending on users’ awareness of their involvement. These approaches present a variety of technological and ethical challenges. An example is represented by Twitter Monitor [ 10 ], that is crowd-sensing tool designed to access Twitter streams through the Twitter Streaming API. It allows launching parallel listening for collecting different sets of data. Twitter Monitor represents a tool for creating services for listening campaigns regarding relevant events such as political elections, natural and human-made disasters, popular national events, etc. [ 11 ]. This campaign can be carried out, specifying keywords, accounts, and geographical areas of interest.

Nowcasting Footnote 5 financial and economic indicators focus on the potential of data science as a proxy for well-being and socioeconomic applications. The development of innovative research methods has demonstrated that poverty indicators can be approximated by social and behavioral mobility metrics extracted from mobile phone data and GPS data [ 34 ]; and the Gross Domestic Product can be accurately nowcasted by using retail supermarket market data [ 18 ]. Furthermore, nowcasting of demographic aspects of territory based on Twitter data [ 1 ] can support official statistics, through the estimation of location, occupation, and semantics. Networks are a convenient way to represent the complex interaction among the elements of a large system. In economics, networks are gaining increasing attention because the underlying topology of a networked system affects the aggregate output, the propagation of shocks, or financial distress; or the topology allows us to learn something about a node by looking at the properties of its neighbors. Among the most investigated financial and economic networks, we cite a work that analyzes the interbank systems, the payment networks between firms, the banks-firms bipartite networks, and the trading network between investors [ 37 ]. Another interesting phenomenon is the advent of blockchain technology that has led to the innovation of bitcoin crypto-currency [ 31 ].

Data science is an excellent opportunity for policy, data journalism, and marketing. The online media arena is now available as a real-time experimenting society for understanding social mechanisms, like harassment, discrimination, hate, and fake news. In our vision, the use of data science approaches is necessary for better governance. These new approaches integrate and change the Official Statistics representing a cheaper and more timely manner of computing them. The impact of data science-driven applications can be particularly significant when the applications help to build new infrastructures or new services for the population.

The availability of massive data portraying soccer performance has facilitated recent advances in soccer analytics. Rossi et al. [ 42 ] proposed an innovative machine learning approach to the forecasting of non-contact injuries for professional soccer players. In [ 3 ], we can find the definition of quantitative measures of pressing in defensive phases in soccer. Pappalardo et al. [ 33 ] outlined the automatic and data-driven evaluation of performance in soccer, a ranking system for soccer teams. Sports data science is attracting much interest and is now leading to the release of a large and public dataset of sports events.

Finally, data science has unveiled a shift from population statistics to interlinked entities statistics, connected by mutual interactions. This change of perspective reveals universal patterns underlying complex social, economic, technological, and biological systems. It is helpful to understand the dynamics of how opinions, epidemics, or innovations spread in our society, as well as the mechanisms behind complex systemic diseases, such as cancer and metabolic disorders revealing hidden relationships between them. Considering diffusive models and dynamic networks, NDlib [ 40 ] is a Python package for the description, simulation, and observation of diffusion processes in complex networks. It collects diffusive models from epidemics and opinion dynamics and allows a scientist to compare simulation over synthetic systems. For community discovery, two tools are available for studying the structure of a community and understand its habits: Demon [ 9 ] extracts ego networks (i.e., the set of nodes connected to an ego node) and identifies the real communities by adopting a democratic, bottom-up merging approach of such structures. Tiles [ 41 ] is dedicated to dynamic network data and extracts overlapping communities and tracks their evolution in time following an online iterative procedure.

2.2 Impact on industry and business

Data science can create an ecosystem of novel data-driven business opportunities. As a general trend across all sectors, massive quantities of data will be made accessible to everybody, allowing entrepreneurs to recognize and to rank shortcomings in business processes, to spot potential threads and win-win situations. Ideally, every citizen could establish from these patterns new business ideas. Co-creation enables data scientists to design innovative products and services. The value of joining different datasets is much larger than the sum of the value of the separated datasets by sharing data of various nature and provenance.

The gains from data science are expected across all sectors, from industry and production to services and retail. In this context, we cite several macro-areas where data science applications are especially promising. In energy and environment , the digitization of the energy systems (from production to distribution) enables the acquisition of real-time, high-resolution data. Coupled with other data sources, such as weather data, usage patterns, and market data (accompanied by advanced analytics), efficiency levels can be increased immensely. The positive impact to the environment is also enhanced by geospatial data that help to understand how our planet and its climate are changing and to confront major issues such as global warming, preservation of the species, the role and effects of human activities.

The manufacturing and production sector with the growing investments into Industry 4.0 and smart factories with sensor-equipped machinery that are both intelligent and networked (see internet of things . Cyber-physical systems ) will be one of the major producers of data in the world. The application of data science into this sector will bring efficiency gains and predictive maintenance. Entirely new business models are expected since the mass production of individualized products becomes possible where consumers may have direct access to influence and control.

As already stated in Sect.  2.1 , data science will contribute to increasing efficiency in public administrations processes and healthcare. In the physical and the cyber-domain, security will be enhanced. From financial fraud to public security, data science will contribute to establishing a framework that enables a safe and secure digital economy. Big data exploitation will open up opportunities for innovative, self-organizing ways of managing logistical business processes. Deliveries could be based on predictive monitoring, using data from stores, semantic product memories, internet forums, and weather forecasts, leading to both economic and environmental savings. Let us also consider the impact of personalized services for creating real experiences for tourists. The analysis of real-time and context-aware data (with the help of historical and cultural heritage data) will provide customized information to each tourist, and it will contribute to the better and more efficient management of the whole tourism value chain.

3 Data science ethics

Data science creates great opportunities but also new risks. The use of advanced tools for data analysis could expose sensitive knowledge of individual persons and could invade their privacy. Data science approaches require access to digital records of personal activities that contain potentially sensitive information. Personal information can be used to discriminate people based on their presumed characteristics. Data-driven algorithms yield classification and prediction models of behavioral traits of individuals, such as credit score, insurance risk, health status, personal preferences, and religious, ethnic, or political orientation, based on personal data disseminated in the digital environment by users (with or often without their awareness). The achievements of data science are the result of re-interpreting available data for analysis goals that differ from the original reasons motivating data collection. For example, mobile phone call records are initially collected by telecom operators for billing and operational aims, but they can be used for accurate and timely demography and human mobility analysis at a country or regional scale. This re-purposing of data clearly shows the importance of legal compliance and data ethics technologies and safeguards to protect privacy and anonymity; to secure data; to engage users; to avoid discrimination and misuse; to account for transparency; and to the purpose of seizing the opportunities of data science while controlling the associated risks.

Several aspects should be considered to avoid to harm individual privacy. Ethical elements should include the: (i) monitoring of the compliance of experiments, research protocols, and applications with ethical and juridical standards; (ii) developing of big data analytics and social mining tools with value-sensitive design and privacy-by-design methodologies; (iii) boosting of excellence and international competitiveness of Europe’s big data research in safe and fair use of big data for research. It is essential to highlight that data scientists using personal and social data also through infrastructures have the responsibility to get acquainted with the fundamental ethical aspects relating to becoming a “data controller.” This aspect has to be considered to define courses for informing and training data scientists about the responsibilities, the possibilities, and the boundaries they have in data manipulation.

Recalling Fig.  2 , it is crucial to inject into the data science pipeline the ethical values of fairness : how to avoid unfair and discriminatory decisions; accuracy : how to provide reliable information; confidentiality : how to protect the privacy of the involved people and transparency : how to make models and decisions comprehensible to all stakeholders. This value-sensitive design has to be aimed at boosting widespread social acceptance of data science, without inhibiting its power. Finally, it is essential to consider also the impact of the General Data Protection Regulation (GDPR) on (i) companies’ duties and how these European companies should comply with the limits in data manipulation the Regulation requires; and on (ii) researchers’ duties and to highlight articles and recitals which specifically mention and explain how research is intended in GDPR’s legal system.

The relationship between big and open data and how they relate to the broad concept of open government

We complete this section with another important aspect related to open data, i.e., accessible public data that people, companies, and organizations can use to launch new ventures, analyze patterns and trends, make data-driven decisions, and solve complex problems. All the definitions of open data include two features: (i) the data must be publicly available for anyone to use, and (ii) data must be licensed in a way that allows for its reuse. All over the world, initiatives are launched to make data open by government agencies and public organizations; listing them is impossible, but an UN initiative has to be mentioned. Global Pulse Footnote 6 meant to implement the vision for a future in which big data is harnessed safely and responsibly as a public good.

Figure 3 shows the relationships between open data and big data. Currently, the problem is not only that government agencies (and some business companies) are collecting personal data about us, but also that we do not know what data are being collected and we do not have access to the information about ourselves. As reported by the World Economic forum in 2013, it is crucial to understand the value of personal data to let the users make informed decisions. A new branch of philosophy and ethics is emerging to handle personal data related issues. On the one hand, in all cases where the data might be used for the social good (i.e., medical research, improvement of public transports, contrasting epidemics), and understanding the personal data value means to correctly evaluate the balance between public benefits and personal loss of protection. On the other hand, when data are aimed to be used for commercial purposes, the value mentioned above might instead translate into simple pricing of personal information that the user might sell to a company for its business. In this context, discrimination discovery consists of searching for a-priori unknown contexts of suspect discrimination against protected-by-law social groups, by analyzing datasets of historical decision records. Machine learning and data mining approaches may be affected by discrimination rules, and these rules may be deeply hidden within obscure artificial intelligence models. Thus, discrimination discovery consists of understanding whether a predictive model makes direct or indirect discrimination. DCube [ 43 ] is a tool for data-driven discrimination discovery, a library of methods on fairness analysis.

It is important to evaluate how a mining model or algorithm takes its decision. The growing field of methods for explainable machine learning provides and continuously expands a set of comprehensive tool-kits [ 21 ]. For example, X-Lib is a library containing state-of-the-art explanation methods organized within a hierarchical structure and wrapped in a similar fashion way such that they can be easily accessed and used from different users. The library provides support for explaining classification on tabular data and images and for explaining the logic of complex decision systems. X-Lib collects, among the others, the following collection of explanation methods: LIME [ 38 ], Anchor [ 39 ], DeepExplain that includes Saliency maps [ 44 ], Gradient * Input, Integrated Gradients, and DeepLIFT [ 46 ]. Saliency method is a library containing code for SmoothGrad [ 45 ], as well as implementations of several other saliency techniques: Vanilla Gradients, Guided Backpropogation, and Grad-CAM. Another improvement in this context is the use of robotics and AI in data preparation, curation, and in detecting bias in data, information and knowledge as well as in the misuse and abuse of these assets when it comes to legal, privacy, and ethical issues and when it comes to transparency and trust. We cannot rely on human beings to do these tasks. We need to exploit the power of robotics and AI to help provide the protections required. Data and information lawyers will play a key role in legal and privacy issues, ethical use of these assets, and the problem of bias in both algorithms and the data, information, and knowledge used to develop analytics solutions. Finally, we can state that data science can help to fill the gap between legislators and technology.

4 Big data ecosystem: the role of research infrastructures

Research infrastructures (RIs) play a crucial role in the advent and development of data science. A social mining experiment exploits the main components of data science depicted in Fig.  1 (i.e., data, infrastructures, analytical methods) to enable multidisciplinary scientists and innovators to extract knowledge and to make the experiment reusable by the scientific community, innovators providing an impact on science and society.

Resources such as data and methods help domain and data scientists to transform research or an innovation question into a responsible data-driven analytical process. This process is executed onto the platform, thus supporting experiments that yield scientific output, policy recommendations, or innovative proofs-of-concept. Furthermore, an operational ethical board’s stewardship is a critical factor in the success of a RI.

An infrastructure typically offers easy-to-use means to define complex analytical processes and workflows , thus bridging the gap between domain experts and analytical technology. In many instances, domain experts may become a reference for their scientific communities, thus facilitating new users engagement within the RI activities. As a collateral feedback effect, experiments will generate new relevant data, methods, and workflows that can be integrated into the platform by data scientists, contributing to the resource expansion of the RI. An experiment designed in a node of the RI and executed on the platform returns its results to the entire RI community.

Well defined thematic environments amplify new experiments achievements towards the vertical scientific communities (and potential stakeholders) by activating appropriate dissemination channels.

4.1 The SoBigData Research Infrastructure

The SoBigData Research Infrastructure Footnote 7 is an ecosystem of human and digital resources, comprising data scientists, analytics, and processes. As shown in Fig.  4 , SoBigData is designed to enable multidisciplinary scientists and innovators to realize social mining experiments and to make them reusable by the scientific communities. All the components have been introduced for implementing data science from raw data management to knowledge extraction, with particular attention to legal and ethical aspects as reported in Fig.  1 . SoBigData supports data science serving a cross-disciplinary community of data scientists studying all the elements of societal complexity from a data- and model-driven perspective.

Currently, SoBigData includes scientific, industrial, and other stakeholders. In particular, our stakeholders are data analysts and researchers (35.6%), followed by companies (33.3%) and policy and lawmakers (20%). The following sections provide a short but comprehensive overview of the services provided by SoBigData RI with special attention on supporting ethical and open data science [ 15 , 16 ].

4.1.1 Resources, facilities, and access opportunities

Over the past decade, Europe has developed world-leading expertise in building and operating e-infrastructures. They are large-scale, federated and distributed online research environments through which researchers can share access to scientific resources (including data, instruments, computing, and communications), regardless of their location. They are meant to support unprecedented scales of international collaboration in science, both within and across disciplines, investing in economy-of-scale and common behavior, policies, best practices, and standards. They shape up a common environment where scientists can create , validate , assess , compare , and share their digital results of science, such as research data and research methods, by using a common “digital laboratory” consisting of agreed-on services and tools.

The SoBigData Research Infrastructure: an ecosystem of human and digital resources, comprising data scientists, analytical methods, and processes. SoBigData enables multidisciplinary scientists and innovators to carry out experiments and to make them reusable by the community

However, the implementation of workflows, possibly following Open Science principles of reproducibility and transparency, is hindered by a multitude of real-world problems. One of the most prominent is that e-infrastructures available to research communities today are far from being well-designed and consistent digital laboratories, neatly designed to share and reuse resources according to common policies, data models, standards, language platforms, and APIs. They are instead “patchworks of systems,” assembling online tools, services, and data sources and evolving to match the requirements of the scientific process, to include new solutions. The degree of heterogeneity excludes the adoption of uniform workflow management systems, standard service-oriented approaches, routine monitoring and accounting methods. The realization of scientific workflows is typically realized by writing ad hoc code, manipulating data on desktops, alternating the execution of online web services, sharing software libraries implementing research methods in different languages, desktop tools, web-accessible execution engines (e.g., Taverna, Knime, Galaxy).

The SoBigData e-infrastructure is based on D4Science services, which provides researchers and practitioners with a working environment where open science practices are transparently promoted, and data science practices can be implemented by minimizing the technological integration cost highlighted above.

D4Science is a deployed instance of the gCube Footnote 8 technology [ 4 ], a software conceived to facilitate the integration of web services, code, and applications as resources of different types in a common framework, which in turn enables the construction of Virtual Research Environments (VREs) [ 7 ] as combinations of such resources (Fig.  5 ). As there is no common framework that can be trusted enough, sustained enough, to convince resource providers that converging to it would be a worthwhile effort, D4Science implements a “system of systems.” In such a framework, resources are integrated with minimal cost, to gain in scalability, performance, accounting, provenance tracking, seamless integration with other resources, visibility to all scientists. The principle is that the cost of “participation” to the framework is on the infrastructure rather than on resource providers. The infrastructure provides the necessary bridges to include and combine resources that would otherwise be incompatible.

D4Science: resources from external systems, virtual research environments, and communities

More specifically, via D4Science, SoBigData scientists can integrate and share resources such as datasets, research methods, web services via APIs, and web applications via Portlets. Resources can then be integrated, combined, and accessed via VREs, intended as web-based working environments tailored to support the needs of their designated communities, each working on a research question. Research methods are integrated as executable code, implementing WPS APIs in different programming languages (e.g., Java, Python, R, Knime, Galaxy), which can be executed via the Data Miner analytics platform in parallel, transparently to the users, over powerful and extensible clusters, and via simple VRE user interfaces. Scientists using Data Miner in the context of a VRE can select and execute the available methods and share the results with other scientists, who can repeat or reproduce the experiment with a simple click.

D4Science VREs are equipped with core services supporting data analysis and collaboration among its users: ( i ) a shared workspace to store and organize any version of a research artifact; ( ii ) a social networking area to have discussions on any topic (including working version and released artifacts) and be informed on happenings; ( iii ) a Data Miner analytics platform to execute processing tasks (research methods) either natively provided by VRE users or borrowed from other VREs to be applied to VRE users’ cases and datasets; and iv ) a catalogue-based publishing platform to make the existence of a certain artifact public and disseminated. Scientists operating within VREs use such facilities continuously and transparently track the record of their research activities (actions, authorship, provenance), as well as products and links between them (lineage) resulting from every phase of the research life cycle, thus facilitating publishing of science according to Open Science principles of transparency and reproducibility [ 5 ].

Today, SoBigData integrates the resources in Table  1 . By means of such resources, SoBigData scientists have created VREs to deliver the so-called SoBigData exploratories : Explainable Machine Learning , Sports Data Science , Migration Studies , Societal Debates , Well-being & Economy , and City of Citizens . Each exploratory includes the resources required to perform Data science workflows in a controlled and shared environment. Resources range from data to methods, described more in detail in the following, together with their exploitation within the exploratories.

All the resources and instruments integrate into SoBigData RI are structured in such a way as to operate within the confines of the current data protection law with the focus on General Data Protection Regulation (GDPR) and ethical analysis of the fundamental values involved in social mining and AI. Each item into the catalogue has specific fields for managing ethical issues (e.g., if a dataset contains personal info) and fields for describing and managing intellectual properties.

4.1.2 Data resources: social mining and big data ecosystem

SoBigData RI defines policies supporting users in the collection, description, preservation, and sharing of their data sets. It implements data science making such data available for collaborative research by adopting various strategies, ranging from sharing the open data sets with the scientific community at large, to share the data with disclosure restriction allowing data access within secure environments.

Several big data sets are available through SoBigData RI including network graphs from mobile phone call data; networks crawled from many online social networks, including Facebook and Flickr, transaction micro-data from diverse retailers, query logs both from search engines and e-commerce, society-wide mobile phone call data records, GPS tracks from personal navigation devices, survey data about customer satisfaction or market research, extensive web archives, billions of tweets, and data from location-aware social networks.

4.1.3 Data science through SoBigData exploratories

Exploratories are thematic environments built on top of the SoBigData RI. An exploratory binds datasets with social mining methods providing the research context for supporting specific data science applications by: (i) providing the scientific context for performing the application. This context can be considered a container for binding specific methods, applications, services, and datasets; (ii) stimulating communities on the effectiveness of the analytical process related to the analysis, promoting scientific dissemination, result sharing, and reproducibility. The use of exploratories promotes the effectiveness of the data science trough research infrastructure services. The following sections report a short description of the six SoBigData exploratories. Figure 6 shows the main thematic areas covered by each exploratory. Due to its nature, Explainable Machine Learning exploratory can be applied to each sector where a black-box machine learning approach is used. The list of exploratories (and the data and methods inside them) are updated continuously and continue to grow over time. Footnote 9

SoBigData covers six thematic areas listed horizontally. Each exploratory covers more than one thematic area

City of citizens. This exploratory aims to collect data science applications and methods related to geo-referenced data. The latter describes the movements of citizens in a city, a territory, or an entire region. There are several studies and different methods that employ a wide variety of data sources to build models about the mobility of people and city characteristics in the scientific literature [ 30 , 32 ]. Like ecosystems, cities are open systems that live and develop utilizing flows of energy, matter, and information. What distinguishes a city from a colony is the human component (i.e., the process of transformation by cultural and technological evolution). Through this combination, cities are evolutionary systems that develop and co-evolve continuously with their inhabitants [ 24 ]. Cities are kaleidoscopes of information generated by a myriad of digital devices weaved into the urban fabric. The inclusion of tracking technologies in personal devices enabled the analysis of large sets of mobility data like GPS traces and call detail records.

Data science applied to human mobility is one of the critical topics investigated in SoBigData thanks to the decennial experience of partners in European projects. The study of human mobility led to the integration into the SoBigData of unique Global Positioning System (GPS) and call detail record (CDR) datasets of people and vehicle movements, and geo-referenced social network data as well as several mobility services: O/D (origin-destination) matrix computation, Urban Mobility Atlas Footnote 10 (a visual interface to city mobility patterns), GeoTopics Footnote 11 (for exploring patterns of urban activity from Foursquare), and predictive models: MyWay Footnote 12 (trajectory prediction), TripBuilder Footnote 13 (tourists to build personalized tours of a city). In human mobility, research questions come from geographers, urbanists, complexity scientists, data scientists, policymakers, and Big Data providers, as well as innovators aiming to provide applications for any service for the smart city ecosystem. The idea is to investigate the impact of political events on the well-being of citizens. This exploratory supports the development of “happiness” and “peace” indicators through text mining/opinion mining pipeline on repositories of online news. These indicators reveal that the level of crime of a territory can be well approximated by analyzing the news related to that territory. Generally, we study the impact of the economy on well-being and vice versa, e.g., also considering the propagation of shocks of financial distress in an economic or financial system crucially depends on the topology of the network interconnecting the different elements.

Well-being and economy. This exploratory tests the hypothesis that well-being is correlated to the business performance of companies. The idea is to combine statistical methods and traditional economic data (typically at low-frequency) with high-frequency data from non-traditional sources, such as, i.e., web, supermarkets, for now-casting economic, socioeconomic and well-being indicators. These indicators allow us to study and measure real-life costs by studying price variation and socioeconomic status inference. Furthermore, this activity supports studies on the correlation between people’s well-being and their social and mobility data. In this context, some basic hypothesis can be summarized as: (i) there are curves of age- and gender-based segregation distribution in boards of companies, which are characteristic to mean credit risk of companies in a region; (ii) low mean credit risk of companies in a region has a positive correlation to well-being; (iii) systemic risk correlates highly with well-being indices at a national level. The final aim is to provide a set of guidelines to national governments, methods, and indices for decision making on regulations affecting companies to improve well-being in the country, also considering effective policies to reduce operational risks such as credit risk, and external threats of companies [ 17 ].

Big Data, analyzed through the lenses of data science, provides means to understand our complex socioeconomic and financial systems. On the one hand, this offers new opportunities to measure the patterns of well-being and poverty at a local and global scale, empowering governments and policymakers with the unprecedented opportunity to nowcast relevant economic quantities and compare different countries, regions, and cities. On the other hand, this allows us to investigate the network underlying the complex systems of economy and finance, and it affects the aggregate output, the propagation of shocks or financial distress and systemic risk.

Societal debates. This exploratory employs data science approaches to answer research questions such as who is participating in public debates? What is the “big picture” response from citizens to a policy, election, referendum, or other political events? This kind of analysis allows scientists, policymakers, and citizens to understand the online discussion surrounding polarized debates [ 14 ]. The personal perception of online discussions on social media is often biased by the so-called filter bubble, in which automatic curation of content and relationships between users negatively affects the diversity of opinions available to them. Making a complete analysis of online polarized debates enables the citizens to be better informed and prepared for political outcomes. By analyzing content and conversations on social media and newspaper articles, data scientists study public debates and also assess public sentiment around debated topics, opinion diffusion dynamics, echo chambers formation and polarized discussions, fake news analysis, and propaganda bots. Misinformation is often the result of a distorted perception of concepts that, although unrelated, suddenly appear together in the same narrative. Understanding the details of this process at an early stage may help to prevent the birth and the diffusion of fake news. The misinformation fight includes the development of dynamical models of misinformation diffusion (possibly in contrast to the spread of mainstream news) as well as models of how attention cycles are accelerated and amplified by the infrastructures of online media.

Another important topic covered by this exploratory concerns the analysis of how social bots activity affects fake news diffusion. Determining whether a human or a bot controls a user account is a complex task. To the best of our knowledge, the only openly accessible solution to detect social bots is Botometer, an API that allows us to interact with an underlying machine learning system. Although Botometer has been proven to be entirely accurate in detecting social bots, it has limitations due to the Twitter API features: hence, an algorithm overcoming the barriers of current recipes is needed.

The resources related to Societal Debates exploratory, especially in the domain of media ecology and the fight against misinformation online, provide easy-to-use services to public bodies, media outlets, and social/political scientists. Furthermore, SoBigData supports new simulation models and experimental processes to validate in vivo the algorithms for fighting misinformation, curbing the pathological acceleration and amplification of online attention cycles, breaking the bubbles, and explore alternative media and information ecosystems.

Migration studies. Data science is also useful to understand the migration phenomenon. Knowledge about the number of immigrants living in a particular region is crucial to devise policies that maximize the benefits for both locals and immigrants. These numbers can vary rapidly in space and time, especially in periods of crisis such as wars or natural disasters.

This exploratory provides a set of data and tools for trying to answer some questions about migration flows. Through this exploratory, a data scientist studies economic models of migration and can observe how migrants choose their destination countries. A scientist can discover what is the meaning of “opportunities” that a country provides to migrants, and whether there are correlations between the number of incoming migrants and opportunities in the host countries [ 8 ]. Furthermore, this exploratory tries to understand how public perception of migration is changing using an opinion mining analysis. For example, social network analysis enables us to analyze the migrant’s social network and discover the structure of the social network for people who decided to start a new life in a different country [ 28 ].

Finally, we can also evaluate current integration indices based on official statistics and survey data, which can be complemented by Big Data sources. This exploratory aims to build combined integration indexes that take into account multiple data sources to evaluate integration on various levels. Such integration includes mobile phone data to understand patterns of communication between immigrants and natives; social network data to assess sentiment towards immigrants and immigration; professional network data (such as LinkedIn) to understand labor market integration, and local data to understand to what extent moving across borders is associated with a change in the cultural norms of the migrants. These indexes are fundamental to evaluate the overall social and economic effects of immigration. The new integration indexes can be applied with various space and time resolutions (small area methods) to obtain a complete image of integration, and complement official index.

Sports data science. The proliferation of new sensing technologies that provide high-fidelity data streams extracted from every game, is changing the way scientists, fans and practitioners conceive sports performance. The combination of these (big) data with the tools of data science provides the possibility to unveil complex models underlying sports performance and enables to perform many challenging tasks: from automatic tactical analysis to data-driven performance ranking; game outcome prediction, and injury forecasting. The idea is to foster research on sports data science in several directions. The application of explainable AI and deep learning techniques can be hugely beneficial to sports data science. For example, by using adversarial learning, we can modify the training plans of players that are associated with high injury risk and develop training plans that maximize the fitness of players (minimizing their injury risk). The use of gaming, simulation, and modeling is another set of tools that can be used by coaching staff to test tactics that can be employed against a competitor. Furthermore, by using deep learning on time series, we can forecast the evolution of the performance of players and search for young talents.

This exploratory examines the factors influencing sports success and how to build simulation tools for boosting both individual and collective performance. Furthermore, this exploratory describes performances employing data, statistics, and models, allowing coaches, fans, and practitioners to understand (and boost) sports performance [ 42 ].

Explainable machine learning. Artificial Intelligence, increasingly based on Big Data analytics, is a disruptive technology of our times. This exploratory provides a forum for studying effects of AI on the future society. In this context, SoBigData studies the future of labor and the workforce, also through data- and model-driven analysis, simulations, and the development of methods that construct human understandable explanations of AI black-box models [ 20 ].

Black box systems for automated decision making map a user’s features into a class that predicts the behavioral traits of individuals, such as credit risk, health status, without exposing the reasons why. Most of the time, the internal reasoning of these algorithms is obscure even to their developers. For this reason, the last decade has witnessed the rise of a black box society. This exploratory is developing a set of techniques and tools which allow data analysts to understand why an algorithm produce a decision. These approaches are designed not for discovering a lack of transparency but also for discovering possible biases inherited by the algorithms from human prejudices and artefacts hidden in the training data (which may lead to unfair or wrong decisions) [ 35 ].

5 Conclusions: individual and collective intelligence

The world’s technological per-capita capacity to store information has roughly doubled every 40 months since the 1980s [ 23 ]. Since 2012, every day 2.5 exabytes (2.5 \(\times \) 10 \(^18\) bytes) of data were created; as of 2014, every day 2.3 zettabytes (2.3 \(\times \) 10 \(^21\) bytes) of data were generated by Super-power high-tech Corporation worldwide. Soon zettabytes of useful public and private data will be widely and openly available. In the next years, smart applications such as smart grids, smart logistics, smart factories, and smart cities will be widely deployed across the continent and beyond. Ubiquitous broadband access, mobile technology, social media, services, and internet of think on billions of devices will have contributed to the explosion of generated data to a total global estimate of 40 zettabytes.

In this work, we have introduced data science as a new challenge and opportunity for the next years. In this context, we have tried to summarize in a concise way several aspects related to data science applications and their impacts on society, considering both the new services available and the new job perspectives. We have also introduced issues in managing data representing human behavior and showed how difficult it is to preserve personal information and privacy. With the introduction of SoBigData RI and exploratories, we have provided virtual environments where it is possible to understand the potentiality of data science in different research contexts.

Concluding, we can state that social dilemmas occur when there is a conflict between the individual and public interest. Such problems also appear in the ecosystem of distributed AI systems (based on data science tools) and humans, with additional difficulties due: on the one hand, to the relative rigidity of the trained AI systems and the necessity of achieving social benefit, and, on the other hand, to the necessity of keeping individuals interested. What are the principles and solutions for individual versus social optimization using AI, and how can an optimum balance be achieved? The answer is still open, but these complex systems have to work on fulfilling collective goals, and requirements, with the challenge that human needs change over time and move from one context to another. Every AI system should operate within an ethical and social framework in understandable, verifiable, and justifiable way. Such systems must, in any case, work within the bounds of the rule of law, incorporating protection of fundamental rights into the AI infrastructure. In other words, the challenge is to develop mechanisms that will result in the system converging to an equilibrium that complies with European values and social objectives (e.g., social inclusion) but without unnecessary losses of efficiency.

Interestingly, data science can play a vital role in enhancing desirable behaviors in the system, e.g., by supporting coordination and cooperation that is, more often than not, crucial to achieving any meaningful improvements. Our ultimate goal is to build the blueprint of a sociotechnical system in which AI not only cooperates with humans but, if necessary, helps them to learn how to collaborate, as well as other desirable behaviors. In this context, it is also essential to understand how to achieve robustness of the human and AI ecosystems in respect of various types of malicious behaviors, such as abuse of power and exploitation of AI technical weaknesses.

We conclude by paraphrasing Stephen Hawking in his Brief Answers to the Big Questions: the availability of data on its own will not take humanity to the future, but its intelligent and creative use will.

http://www.sdss3.org/collaboration/ .

e.g., https://www.nature.com/sdata/policies/repositories .

Responsible Data Science program: https://redasci.org/ .

https://emergency.copernicus.eu/ .

Nowcasting in economics is the prediction of the present, the very near future, and the very recent past state of an economic indicator.

https://www.unglobalpulse.org/ .

http://sobigdata.eu .

https://www.gcube-system.org/ .

https://sobigdata.d4science.org/catalogue-sobigdata .

http://www.sobigdata.eu/content/urban-mobility-atlas .

http://data.d4science.org/ctlg/ResourceCatalogue/geotopics_-_a_method_and_system_to_explore_urban_activity .

http://data.d4science.org/ctlg/ResourceCatalogue/myway_-_trajectory_prediction .

http://data.d4science.org/ctlg/ResourceCatalogue/tripbuilder .

Abitbol, J.L., Fleury, E., Karsai, M.: Optimal proxy selection for socioeconomic status inference on twitter. Complexity 2019 , 60596731–605967315 (2019). https://doi.org/10.1155/2019/6059673

Article   Google Scholar  

Amato, G., Candela, L., Castelli, D., Esuli, A., Falchi, F., Gennaro, C., Giannotti, F., Monreale, A., Nanni, M., Pagano, P., Pappalardo, L., Pedreschi, D., Pratesi, F., Rabitti, F., Rinzivillo, S., Rossetti, G., Ruggieri, S., Sebastiani, F., Tesconi, M.: How data mining and machine learning evolved from relational data base to data science. In: Flesca, S., Greco, S., Masciari, E., Saccà, D. (eds.) A Comprehensive Guide Through the Italian Database Research Over the Last 25 Years, Studies in Big Data, vol. 31, pp. 287–306. Springer, Berlin (2018). https://doi.org/10.1007/978-3-319-61893-7_17

Chapter   Google Scholar  

Andrienko, G.L., Andrienko, N.V., Budziak, G., Dykes, J., Fuchs, G., von Landesberger, T., Weber, H.: Visual analysis of pressure in football. Data Min. Knowl. Discov. 31 (6), 1793–1839 (2017). https://doi.org/10.1007/s10618-017-0513-2

Article   MathSciNet   Google Scholar  

Assante, M., Candela, L., Castelli, D., Cirillo, R., Coro, G., Frosini, L., Lelii, L., Mangiacrapa, F., Marioli, V., Pagano, P., Panichi, G., Perciante, C., Sinibaldi, F.: The gcube system: delivering virtual research environments as-a-service. Future Gener. Comput. Syst. 95 , 445–453 (2019). https://doi.org/10.1016/j.future.2018.10.035

Assante, M., Candela, L., Castelli, D., Cirillo, R., Coro, G., Frosini, L., Lelii, L., Mangiacrapa, F., Pagano, P., Panichi, G., Sinibaldi, F.: Enacting open science by d4science. Future Gener. Comput. Syst. (2019). https://doi.org/10.1016/j.future.2019.05.063

Barabasi, A.L., Gulbahce, N., Loscalzo, J.: Network medicine: a network-based approach to human disease. Nature reviews. Genetics 12 , 56–68 (2011). https://doi.org/10.1038/nrg2918

Candela, L., Castelli, D., Pagano, P.: Virtual research environments: an overview and a research agenda. Data Sci. J. 12 , GRDI75–GRDI81 (2013). https://doi.org/10.2481/dsj.GRDI-013

Coletto, M., Esuli, A., Lucchese, C., Muntean, C.I., Nardini, F.M., Perego, R., Renso, C.: Sentiment-enhanced multidimensional analysis of online social networks: perception of the mediterranean refugees crisis. In: Proceedings of the 2016 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, ASONAM’16, pp. 1270–1277. IEEE Press, Piscataway, NJ, USA (2016). http://dl.acm.org/citation.cfm?id=3192424.3192657

Coscia, M., Rossetti, G., Giannotti, F., Pedreschi, D.: Uncovering hierarchical and overlapping communities with a local-first approach. TKDD 9 (1), 6:1–6:27 (2014). https://doi.org/10.1145/2629511

Cresci, S., Minutoli, S., Nizzoli, L., Tardelli, S., Tesconi, M.: Enriching digital libraries with crowdsensed data. In: P. Manghi, L. Candela, G. Silvello (eds.) Digital Libraries: Supporting Open Science—15th Italian Research Conference on Digital Libraries, IRCDL 2019, Pisa, Italy, 31 Jan–1 Feb 2019, Proceedings, Communications in Computer and Information Science, vol. 988, pp. 144–158. Springer (2019). https://doi.org/10.1007/978-3-030-11226-4_12

Cresci, S., Petrocchi, M., Spognardi, A., Tognazzi, S.: Better safe than sorry: an adversarial approach to improve social bot detection. In: P. Boldi, B.F. Welles, K. Kinder-Kurlanda, C. Wilson, I. Peters, W.M. Jr. (eds.) Proceedings of the 11th ACM Conference on Web Science, WebSci 2019, Boston, MA, USA, June 30–July 03, 2019, pp. 47–56. ACM (2019). https://doi.org/10.1145/3292522.3326030

Cresci, S., Pietro, R.D., Petrocchi, M., Spognardi, A., Tesconi, M.: Social fingerprinting: detection of spambot groups through dna-inspired behavioral modeling. IEEE Trans. Dependable Sec. Comput. 15 (4), 561–576 (2018). https://doi.org/10.1109/TDSC.2017.2681672

Furletti, B., Trasarti, R., Cintia, P., Gabrielli, L.: Discovering and understanding city events with big data: the case of rome. Information 8 (3), 74 (2017). https://doi.org/10.3390/info8030074

Garimella, K., De Francisci Morales, G., Gionis, A., Mathioudakis, M.: Reducing controversy by connecting opposing views. In: Proceedings of the 10th ACM International Conference on Web Search and Data Mining, WSDM’17, pp. 81–90. ACM, New York, NY, USA (2017). https://doi.org/10.1145/3018661.3018703

Giannotti, F., Trasarti, R., Bontcheva, K., Grossi, V.: Sobigdata: social mining & big data ecosystem. In: P. Champin, F.L. Gandon, M. Lalmas, P.G. Ipeirotis (eds.) Companion of the The Web Conference 2018 on The Web Conference 2018, WWW 2018, Lyon , France, April 23–27, 2018, pp. 437–438. ACM (2018). https://doi.org/10.1145/3184558.3186205

Grossi, V., Rapisarda, B., Giannotti, F., Pedreschi, D.: Data science at sobigdata: the european research infrastructure for social mining and big data analytics. I. J. Data Sci. Anal. 6 (3), 205–216 (2018). https://doi.org/10.1007/s41060-018-0126-x

Grossi, V., Romei, A., Ruggieri, S.: A case study in sequential pattern mining for it-operational risk. In: W. Daelemans, B. Goethals, K. Morik (eds.) Machine Learning and Knowledge Discovery in Databases, European Conference, ECML/PKDD 2008, Antwerp, Belgium, 15–19 Sept 2008, Proceedings, Part I, Lecture Notes in Computer Science, vol. 5211, pp. 424–439. Springer (2008). https://doi.org/10.1007/978-3-540-87479-9_46

Guidotti, R., Coscia, M., Pedreschi, D., Pennacchioli, D.: Going beyond GDP to nowcast well-being using retail market data. In: A. Wierzbicki, U. Brandes, F. Schweitzer, D. Pedreschi (eds.) Advances in Network Science—12th International Conference and School, NetSci-X 2016, Wroclaw, Poland, 11–13 Jan 2016, Proceedings, Lecture Notes in Computer Science, vol. 9564, pp. 29–42. Springer (2016). https://doi.org/10.1007/978-3-319-28361-6_3

Guidotti, R., Monreale, A., Nanni, M., Giannotti, F., Pedreschi, D.: Clustering individual transactional data for masses of users. In: Proceedings of the 23rd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, Halifax, NS, Canada, 13–17 Aug 2017, pp. 195–204. ACM (2017). https://doi.org/10.1145/3097983.3098034

Guidotti, R., Monreale, A., Ruggieri, S., Turini, F., Giannotti, F., Pedreschi, D.: A survey of methods for explaining black box models. ACM Comput. Surv. 51 (5), 93:1–93:42 (2019). https://doi.org/10.1145/3236009

Guidotti, R., Monreale, A., Turini, F., Pedreschi, D., Giannotti, F.: A survey of methods for explaining black box models. CoRR abs/1802.01933 (2018). arxiv: 1802.01933

Guidotti, R., Nanni, M., Rinzivillo, S., Pedreschi, D., Giannotti, F.: Never drive alone: boosting carpooling with network analysis. Inf. Syst. 64 , 237–257 (2017). https://doi.org/10.1016/j.is.2016.03.006

Hilbert, M., Lopez, P.: The world’s technological capacity to store, communicate, and compute information. Science 332 (6025), 60–65 (2011)

Kennedy, C.A., Stewart, I., Facchini, A., Cersosimo, I., Mele, R., Chen, B., Uda, M., Kansal, A., Chiu, A., Kim, K.g., Dubeux, C., Lebre La Rovere, E., Cunha, B., Pincetl, S., Keirstead, J., Barles, S., Pusaka, S., Gunawan, J., Adegbile, M., Nazariha, M., Hoque, S., Marcotullio, P.J., González Otharán, F., Genena, T., Ibrahim, N., Farooqui, R., Cervantes, G., Sahin, A.D., : Energy and material flows of megacities. Proc. Nat. Acad. Sci. 112 (19), 5985–5990 (2015). https://doi.org/10.1073/pnas.1504315112

Korjani, S., Damiano, A., Mureddu, M., Facchini, A., Caldarelli, G.: Optimal positioning of storage systems in microgrids based on complex networks centrality measures. Sci. Rep. (2018). https://doi.org/10.1038/s41598-018-35128-6

Lorini, V., Castillo, C., Dottori, F., Kalas, M., Nappo, D., Salamon, P.: Integrating social media into a pan-european flood awareness system: a multilingual approach. In: Z. Franco, J.J. González, J.H. Canós (eds.) Proceedings of the 16th International Conference on Information Systems for Crisis Response and Management, València, Spain, 19–22 May 2019. ISCRAM Association (2019). http://idl.iscram.org/files/valeriolorini/2019/1854-_ValerioLorini_etal2019.pdf

Lulli, A., Gabrielli, L., Dazzi, P., Dell’Amico, M., Michiardi, P., Nanni, M., Ricci, L.: Scalable and flexible clustering solutions for mobile phone-based population indicators. Int. J. Data Sci. Anal. 4 (4), 285–299 (2017). https://doi.org/10.1007/s41060-017-0065-y

Moise, I., Gaere, E., Merz, R., Koch, S., Pournaras, E.: Tracking language mobility in the twitter landscape. In: C. Domeniconi, F. Gullo, F. Bonchi, J. Domingo-Ferrer, R.A. Baeza-Yates, Z. Zhou, X. Wu (eds.) IEEE International Conference on Data Mining Workshops, ICDM Workshops 2016, 12–15 Dec 2016, Barcelona, Spain., pp. 663–670. IEEE Computer Society (2016). https://doi.org/10.1109/ICDMW.2016.0099

Nanni, M.: Advancements in mobility data analysis. In: F. Leuzzi, S. Ferilli (eds.) Traffic Mining Applied to Police Activities—Proceedings of the 1st Italian Conference for the Traffic Police (TRAP-2017), Rome, Italy, 25–26 Oct 2017, Advances in Intelligent Systems and Computing, vol. 728, pp. 11–16. Springer (2017). https://doi.org/10.1007/978-3-319-75608-0_2

Nanni, M., Trasarti, R., Monreale, A., Grossi, V., Pedreschi, D.: Driving profiles computation and monitoring for car insurance crm. ACM Trans. Intell. Syst. Technol. 8 (1), 14:1–14:26 (2016). https://doi.org/10.1145/2912148

Pappalardo, G., di Matteo, T., Caldarelli, G., Aste, T.: Blockchain inefficiency in the bitcoin peers network. EPJ Data Sci. 7 (1), 30 (2018). https://doi.org/10.1140/epjds/s13688-018-0159-3

Pappalardo, L., Barlacchi, G., Pellungrini, R., Simini, F.: Human mobility from theory to practice: Data, models and applications. In: S. Amer-Yahia, M. Mahdian, A. Goel, G. Houben, K. Lerman, J.J. McAuley, R.A. Baeza-Yates, L. Zia (eds.) Companion of The 2019 World Wide Web Conference, WWW 2019, San Francisco, CA, USA, 13–17 May 2019., pp. 1311–1312. ACM (2019). https://doi.org/10.1145/3308560.3320099

Pappalardo, L., Cintia, P., Ferragina, P., Massucco, E., Pedreschi, D., Giannotti, F.: Playerank: data-driven performance evaluation and player ranking in soccer via a machine learning approach. ACM TIST 10 (5), 59:1–59:27 (2019). https://doi.org/10.1145/3343172

Pappalardo, L., Vanhoof, M., Gabrielli, L., Smoreda, Z., Pedreschi, D., Giannotti, F.: An analytical framework to nowcast well-being using mobile phone data. CoRR abs/1606.06279 (2016). arxiv: 1606.06279

Pasquale, F.: The Black Box Society: The Secret Algorithms That Control Money and Information. Harvard University Press, Cambridge (2015)

Book   Google Scholar  

Piškorec, M., Antulov-Fantulin, N., Miholić, I., Šmuc, T., Šikić, M.: Modeling peer and external influence in online social networks: Case of 2013 referendum in croatia. In: Cherifi, C., Cherifi, H., Karsai, M., Musolesi, M. (eds.) Complex Networks & Their Applications VI. Springer, Cham (2018)

Google Scholar  

Ranco, G., Aleksovski, D., Caldarelli, G., Mozetic, I.: Investigating the relations between twitter sentiment and stock prices. CoRR abs/1506.02431 (2015). arxiv: 1506.02431

Ribeiro, M.T., Singh, S., Guestrin, C.: “why should I trust you?”: Explaining the predictions of any classifier. In: B. Krishnapuram, M. Shah, A.J. Smola, C.C. Aggarwal, D. Shen, R. Rastogi (eds.) Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, San Francisco, CA, USA, 13–17 Aug 2016, pp. 1135–1144. ACM (2016). https://doi.org/10.1145/2939672.2939778

Ribeiro, M.T., Singh, S., Guestrin, C.: Anchors: High-precision model-agnostic explanations. In: S.A. McIlraith, K.Q. Weinberger (eds.) Proceedings of the Thirty-Second AAAI Conference on Artificial Intelligence, (AAAI-18), the 30th innovative Applications of Artificial Intelligence (IAAI-18), and the 8th AAAI Symposium on Educational Advances in Artificial Intelligence (EAAI-18), New Orleans, Louisiana, USA, 2–7 Feb 2018, pp. 1527–1535. AAAI Press (2018). https://www.aaai.org/ocs/index.php/AAAI/AAAI18/-paper/view/16982

Rossetti, G., Milli, L., Rinzivillo, S., Sîrbu, A., Pedreschi, D., Giannotti, F.: Ndlib: a python library to model and analyze diffusion processes over complex networks. Int. J. Data Sci. Anal. 5 (1), 61–79 (2018). https://doi.org/10.1007/s41060-017-0086-6

Rossetti, G., Pappalardo, L., Pedreschi, D., Giannotti, F.: Tiles: an online algorithm for community discovery in dynamic social networks. Mach. Learn. 106 (8), 1213–1241 (2017). https://doi.org/10.1007/s10994-016-5582-8

Rossi, A., Pappalardo, L., Cintia, P., Fernández, J., Iaia, M.F., Medina, D.: Who is going to get hurt? predicting injuries in professional soccer. In: J. Davis, M. Kaytoue, A. Zimmermann (eds.) Proceedings of the 4th Workshop on Machine Learning and Data Mining for Sports Analytics co-located with 2017 European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML PKDD 2017), Skopje, Macedonia, 18 Sept 2017., CEUR Workshop Proceedings, vol. 1971, pp. 21–30. CEUR-WS.org (2017). http://ceur-ws.org/Vol-1971/paper-04.pdf

Ruggieri, S., Pedreschi, D., Turini, F.: DCUBE: discrimination discovery in databases. In: A.K. Elmagarmid, D. Agrawal (eds.) Proceedings of the ACM SIGMOD International Conference on Management of Data, SIGMOD 2010, Indianapolis, Indiana, USA, 6–10 June 2010, pp. 1127–1130. ACM (2010). https://doi.org/10.1145/1807167.1807298

Simonyan, K., Vedaldi, A., Zisserman, A.: Deep inside convolutional networks: Visualising image classification models and saliency maps. CoRR abs/1312.6034 (2013). http://dblp.uni-trier.de/db/journals/corr/corr1312.html#SimonyanVZ13

Smilkov, D., Thorat, N., Kim, B., Viégas, F.B., Wattenberg, M.: Smoothgrad: removing noise by adding noise. CoRR abs/1706.03825 (2017). arxiv: 1706.03825

Sundararajan, M., Taly, A., Yan, Q.: Axiomatic attribution for deep networks. In: D. Precup, Y.W. Teh (eds.) Proceedings of the 34th International Conference on Machine Learning, Proceedings of Machine Learning Research, vol. 70, pp. 3319–3328. PMLR, International Convention Centre, Sydney, Australia (2017). http://proceedings.mlr.press/v70/sundararajan17a.html

Trasarti, R., Guidotti, R., Monreale, A., Giannotti, F.: Myway: location prediction via mobility profiling. Inf. Syst. 64 , 350–367 (2017). https://doi.org/10.1016/j.is.2015.11.002

Traub, J., Quiané-Ruiz, J., Kaoudi, Z., Markl, V.: Agora: Towards an open ecosystem for democratizing data science & artificial intelligence. CoRR abs/1909.03026 (2019). arxiv: 1909.03026

Vazifeh, M.M., Zhang, H., Santi, P., Ratti, C.: Optimizing the deployment of electric vehicle charging stations using pervasive mobility data. Transp Res A Policy Practice 121 (C), 75–91 (2019). https://doi.org/10.1016/j.tra.2019.01.002

Vermeulen, A.F.: Practical Data Science: A Guide to Building the Technology Stack for Turning Data Lakes into Business Assets, 1st edn. Apress, New York (2018)

Download references

Acknowledgements

This work is supported by the European Community’s H2020 Program under the scheme ‘INFRAIA-1-2014-2015: Research Infrastructures’, grant agreement #654024 ‘SoBigData: Social Mining and Big Data Ecosystem’ and the scheme ‘INFRAIA-01-2018-2019: Research and Innovation action’, grant agreement #871042 ’SoBigData \(_{++}\) : European Integrated Infrastructure for Social Mining and Big Data Analytics’

Open access funding provided by Università di Pisa within the CRUI-CARE Agreement.

Author information

Authors and affiliations.

CNR - Istituto Scienza e Tecnologia dell’Informazione A. Faedo, KDDLab, Pisa, Italy

Valerio Grossi & Fosca Giannotti

Department of Computer Science, University of Pisa, Pisa, Italy

Dino Pedreschi

CNR - Istituto Scienza e Tecnologia dell’Informazione A. Faedo, NeMIS, Pisa, Italy

Paolo Manghi, Pasquale Pagano & Massimiliano Assante

You can also search for this author in PubMed   Google Scholar

Corresponding author

Correspondence to Dino Pedreschi .

Additional information

Publisher's note.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .

Reprints and permissions

About this article

Grossi, V., Giannotti, F., Pedreschi, D. et al. Data science: a game changer for science and innovation. Int J Data Sci Anal 11 , 263–278 (2021). https://doi.org/10.1007/s41060-020-00240-2

Download citation

Received : 13 July 2019

Accepted : 15 December 2020

Published : 19 April 2021

Issue Date : May 2021

DOI : https://doi.org/10.1007/s41060-020-00240-2

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

• Responsible data science
• Research infrastructure
• Social mining
• Find a journal
• Publish with us
• Track your research

• Find My Rep

You are here

Science, Technology and Society

Preview this book.

• Description
• Aims and Scope
• Editorial Board
• Abstracting / Indexing
• Submission Guidelines

Science, Technology & Society enhances our understanding of the way in which advances in science and technology influence society and vice versa. Launched in 1996, it is the first truly international journal devoted to the developing world and published from the region. It covers areas like history, sociology, philosophy, economics, political science, psychology, technological forecasting, science policy, R & D management, health & nutrition, agriculture, ecology & environment, and quantitative studies.

Science, Technology and Society promotes interdisciplinary perspectives drawing upon a number of "hard core" science disciplines.

"…Despite its high standard of scholarship, the journal is designed to be accessible to a broad range of scientists working in R&D fields. It should be on the essential reading lists of all scientists with an interest in developing countries". - NATURE

Electronic Access: Science Technology & Society is available electronically on SAGE Journals Online at http://journals.sagepub.com/home/STS This journal is a member of the Committee on Publication Ethics (COPE) .

Science, Technology and Society is an international journal devoted to the study of science and technology in social context. It focuses on the way in which advances in science and technology influence society and vice versa. It is a peer-reviewed journal that takes an interdisciplinary perspective, encouraging analyses whose approaches are drawn from a variety of disciplines such as history, sociology, philosophy, economics, political science and international relations, science policy involving innovation, foresight studies involving science and technology, technology management, environmental studies, energy studies and gender studies. The journal consciously endeavors to combine scholarly perspectives relevant to academic research and policy issues relating to development. Besides research articles the journal encourages research-based country reports, commentaries and book reviews.

• Australian Business Deans Council (ABDC)
• Chartered Association of Business Schools (CABS)
• Clarivate Analytics: Social Science Citation Index (SSCI)
• Indian Citation Index (ICI)
• National Academy of Agricultural Sciences (NAAS)
• Pro-Quest-RSP
• ProQuest: International Bibliography of the Social Sciences (IBSS)
• UGC-CARE (GROUP II)

Submission Guidelines for Science, Technology and Society

•  Manuscripts and all editorial correspondence should be addressed to: Prof V V Krishna, Editor in Chief, Science, Technology and Society Journal, School of Humanities and Languages, 258, Level 2, Morven Brown Building,  University of New South Wales, Sydney, Australia 2052 (E-mail: [email protected] ).
•  Contributors must provide their affiliations and complete postal and E-mail addresses with their papers. If there are two or more authors, then the corresponding author’s name and address details must be specified clearly.  
• Authors will be provided with a copyright form once the contribution is accepted for publication. The submission will be considered as final only after the filled-in and signed copyright form is received. In case there are two or more authors, the corresponding author needs to sign the copyright form.  
• All articles should be typed on one side of the paper (preferably A4) and double-spaced throughout (not only the text, but also displayed quotations, notes, references and any other matter). Manuscripts should be submitted in MS Word format. All articles must be accompanied by an abstract of 150–200 words and 4–6 keywords.  
• Notes should be numbered serially and presented at the end of the article. Notes must contain more than a mere reference.  
• British spellings throughout; universal ‘ s ’ in ‘ -ise ’ and ‘ -isation ’ words.  
• Use single quotes throughout. Double quotes only within single quotes. Spellings of words in quotations should not be changed. Quotations of 45 words or more should be separated from the text and indented with one space with a line space above and below.  
• Use ‘nineteenth century’, ‘1980s’. Spell out numbers from one to ninety-nine, 100 and above to remain in figures. However, for exact measurements use only figures (3 km, 9 per cent not %). Use thousands and millions, not lakhs and crores.  
• Use of italics and diacriticals should be minimised, but used consistently.  
• Tables and figures to be indicated by numbers separately (see Table 1), not by placement (see Table below). Present each table and figure on a separate sheet of paper, gathering them together at the end of the article. All figures and tables should be cited in the text. Source for figures and tables should be mentioned irrespective of whether or not they require permissions.  
• All photographs and scanned images should have a resolution of minimum 300 dpi and 1500 pixels and their format should be TIFF or JPEG. Due permissions should be taken for copyright protected photographs/images. Even for photographs/images available in the public domain, it should be clearly ascertained whether or not their reproduction requires permission for purposes of publishing (which is a profit-making endeavor). All photographs/scanned images should be provided separately.  

Arrangement of references: Reference list entries should be alphabetized by the last name of the first author of each work. In each reference, authors’ names are inverted (last name first) for all authors (first, second or subsequent ones); give the last name and initials for all authors of a particular work unless the work has more than six authors. If the work has more than six authors, list the first six authors and then use et al. after the sixth author’s name.

Chronological listing: If more than one work by the same author(s) is cited, they should be listed in order by the year of publication, starting with the earliest.

Sentence case: In references, sentence case (only the first word and any proper noun are capitalized – e.g., ‘The software industry in India’) is to be followed for the titles of papers, books, articles, etc.

Title case: In references, Journal titles are put in title case (first letter of all words except articles and conjunctions are capitalized – e.g., Journal of Business Ethics).

In text citations:

One work by one author: (Kessler, 2003, p. 50) or ‘Kessler (2003) found that among the epidemiological samples..’

One work by two authors: (Joreskog & Sorborn, 2007, pp. 50–66) or Joreskog and Sorborn (2007) found that..

One work by three or more authors: (Basu, Banerji & Chatterjee, 2007) [first instance]; Basu et al. (2007) [Second instance onwards]. 

Groups or organizations or universities: (University of Pittsburgh, 2007) or University of Pittsburgh (2007).

Authors with same surname: Include the initials in all the in-text citations even if the year of publication differs, e.g., (I. Light, 2006; M.A. Light, 2008).

Works with no identified author or anonymous author: Cite the first few words of the reference entry (title) and then the year, e.g., (‘Study finds’, 2007); (Anonymous, 1998). If abbreviations are provided, then the style to be followed is: (National Institute of Mental Health[NIMH], 2003) in the first citation and (NIMH, 2003) in subsequent citations.

Two or more works by same author: (Gogel, 1990, 2006, in press)

Two or more works with different authors: (Gogel, 1996; Miller, 1999)

Secondary sources: Allport's diary (as cited in Nicholson, 2003).

References:

Books: Patnaik, Utsa (2007). The republic of hunger . New Delhi: Three Essays Collective. Patnaik, Utsa (2007). . New Delhi: Three Essays Collective.

Edited Books: Amanor, Kojo S., & Moyo, S. (Eds) (2008). Land and sustainable development in Africa . London and New York: Zed Books. Amanor, Kojo S., & Moyo, S. (Eds) (2008). . London and New York: Zed Books.

Translated books: Amin, S. (1976). Unequal development (trans. B. Pearce). London and New York: Monthly Review Press.

Book chapters: Chachra, S. (2011). The national question in India. In S. Moyo and P. Yeros (Eds), Reclaiming the nation (pp. 67–78). London and New York: Pluto Press.

Journal articles: Foster, J.B. (2010). The financialization of accumulation. Monthly Review , 62 (5),1-17. doi: 10.1037/0278-6133.24.2.225 [DOI number optional]

Newsletter article, no author: Six sites meet for comprehensive anti-gang intiative conference. (2006, November/December). OOJDP News @ a Glance. Retrieved from http://www.ncrjs.gov/html [Please do not place a period at the end of an online reference.]

Newspaper article: Schwartz, J. (1993, September 30). Obesity affects economic, social status. The Washington Post , pp. A1, A4. Schwartz, J. (1993, September 30). Obesity affects economic, social status. , pp. A1, A4.

In-press article: Briscoe, R. (in press). Egocentric spatial representation in action and perception. Philosophy and Phenomenological Research. Retrieved from http://cogprints.org/5780/1/ECSRAP.F07.pdf

Non-English reference book, title translated into English: Real Academia Espanola. (2001). Diccionario de la lengua espanola [Dictionary of the Spanish Language] (22nd ed.). Madrid, Spain: Author.

• Book reviews must contain name of author/editor and book reviewed, place of publication and publisher, year of publication, number of pages and price.

Publication ethics

Sage is committed to upholding the integrity of the academic record. We encourage authors to refer to the Committee on Publication Ethics’ International Standards for Authors and view the Publication Ethics page on the Sage Author Gateway

• Read Online
• Sample Issues
• Current Issue
• Email Alert
• Permissions
• Foreign rights
• Reprints and sponsorship
• Advertising

Individual Subscription, Print Only

Institutional Backfile Purchase, E-access (Content through 1998)

Institutional Subscription, E-access

Institutional Subscription & Backfile Lease, E-access Plus Backfile (All Online Content)

Institutional Subscription, Print Only

Institutional Subscription, Combined (Print & E-access)

Institutional Subscription & Backfile Lease, Combined Plus Backfile (Current Volume Print & All Online Content)

Individual, Single Print Issue

Institutional, Single Print Issue

Subscription Information

To purchase a non-standard subscription or a back issue, please contact SAGE Customer Services for availability.

[email protected]  +44 (0) 20 7324 8701

Cultural Relativity and Acceptance of Embryonic Stem Cell Research

Article sidebar.

Main Article Content

There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole. Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

[1] Poliwoda, S., Noor, N., Downs, E., Schaaf, A., Cantwell, A., Ganti, L., Kaye, A. D., Mosel, L. I., Carroll, C. B., Viswanath, O., & Urits, I. (2022). Stem cells: a comprehensive review of origins and emerging clinical roles in medical practice.  Orthopedic reviews ,  14 (3), 37498. https://doi.org/10.52965/001c.37498

[2] Poliwoda, S., Noor, N., Downs, E., Schaaf, A., Cantwell, A., Ganti, L., Kaye, A. D., Mosel, L. I., Carroll, C. B., Viswanath, O., & Urits, I. (2022). Stem cells: a comprehensive review of origins and emerging clinical roles in medical practice.  Orthopedic reviews ,  14 (3), 37498. https://doi.org/10.52965/001c.37498

[3] International Society for Stem Cell Research. (2023). Laboratory-based human embryonic stem cell research, embryo research, and related research activities . International Society for Stem Cell Research. https://www.isscr.org/guidelines/blog-post-title-one-ed2td-6fcdk ; Kimmelman, J., Hyun, I., Benvenisty, N.  et al.  Policy: Global standards for stem-cell research.  Nature   533 , 311–313 (2016). https://doi.org/10.1038/533311a

[4] International Society for Stem Cell Research. (2023). Laboratory-based human embryonic stem cell research, embryo research, and related research activities . International Society for Stem Cell Research. https://www.isscr.org/guidelines/blog-post-title-one-ed2td-6fcdk

[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

Sandel M. J. (2004). Embryo ethics--the moral logic of stem-cell research.  The New England journal of medicine ,  351 (3), 207–209. https://doi.org/10.1056/NEJMp048145 ; George, R. P., & Lee, P. (2020, September 26). Acorns and Embryos . The New Atlantis. https://www.thenewatlantis.com/publications/acorns-and-embryos ; Sagan, A., & Singer, P. (2007). The moral status of stem cells. Metaphilosophy , 38 (2/3), 264–284. http://www.jstor.org/stable/24439776 ; McHugh P. R. (2004). Zygote and "clonote"--the ethical use of embryonic stem cells.  The New England journal of medicine ,  351 (3), 209–211. https://doi.org/10.1056/NEJMp048147 ; Kurjak, A., & Tripalo, A. (2004). The facts and doubts about beginning of the human life and personality.  Bosnian journal of basic medical sciences ,  4 (1), 5–14. https://doi.org/10.17305/bjbms.2004.3453

[6] Vazin, T., & Freed, W. J. (2010). Human embryonic stem cells: derivation, culture, and differentiation: a review.  Restorative neurology and neuroscience ,  28 (4), 589–603. https://doi.org/10.3233/RNN-2010-0543

[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

[8] Sherley v. Sebelius , 644 F.3d 388 (D.C. Cir. 2011), citing 45 C.F.R. 46.204(b) and [42 U.S.C. § 289g(b)]. https://www.cadc.uscourts.gov/internet/opinions.nsf/6c690438a9b43dd685257a64004ebf99/$file/11-5241-1391178.pdf

[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

[11] Hurlbut, W. B. (2006). Science, Religion, and the Politics of Stem Cells.  Social Research ,  73 (3), 819–834. http://www.jstor.org/stable/40971854

[12] Akpa-Inyang, Francis & Chima, Sylvester. (2021). South African traditional values and beliefs regarding informed consent and limitations of the principle of respect for autonomy in African communities: a cross-cultural qualitative study. BMC Medical Ethics . 22. 10.1186/s12910-021-00678-4.

[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

[14] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics , 22 (2), 112–122. https://doi.org/10.1111/dewb.12324

[15] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics, 22(2), 112–122. https://doi.org/10.1111/dewb.12324

[16] Jackson, C.S., Pepper, M.S. Opportunities and barriers to establishing a cell therapy programme in South Africa.  Stem Cell Res Ther   4 , 54 (2013). https://doi.org/10.1186/scrt204 ; Pew Research Center. (2014, May 1). Public health a major priority in African nations . Pew Research Center’s Global Attitudes Project. https://www.pewresearch.org/global/2014/05/01/public-health-a-major-priority-in-african-nations/

[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[19] United States Bureau of Citizenship and Immigration Services. (1998). Tunisia: Information on the status of Christian conversions in Tunisia . UNHCR Web Archive. https://webarchive.archive.unhcr.org/20230522142618/https://www.refworld.org/docid/3df0be9a2.html

[20] Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

[25] Li, X.-T., & Zhao, J. (2012). Chapter 4: An Approach to the Nature of Qi in TCM- Qi and Bioenergy. In Recent Advances in Theories and Practice of Chinese Medicine (p. 79). InTech.

[26] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[27] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[28] Zhang, J. Y. (2017). Lost in translation? accountability and governance of Clinical Stem Cell Research in China. Regenerative Medicine , 12 (6), 647–656. https://doi.org/10.2217/rme-2017-0035

[29] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

[80] Benjamin, R. (2013). People’s science bodies and rights on the Stem Cell Frontier . Stanford University Press.

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License .