ВШЭ 2020 доклад студента: антидепрессанты и их экономика
COMMENTS
Major depressive disorder: Validated treatments and future challenges
Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning. Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning. Pharmacotherapy, especially selective serotonin reuptake ...
Treatment outcomes for depression: challenges and opportunities
Our lack of knowledge cannot be put down to a scarcity of research in existing treatments. In the past decades, more than 500 randomised trials have examined the effects of antidepressant medications, and more than 600 trials have examined the effects of psychotherapies for depression (although comparatively few are conducted for early-onset depression).
Use of Antidepressants among Patients Diagnosed with Depression: A
2.2.1. Inclusion Criteria . Inclusion criteria are the following: (1) literatures of varying methodologies such as observational, cross-sectional, and retrospective studies, survey, and case reports, (2) studies conducted on all patients aged ≥18 years with a primary diagnosis of depression and prescription of at least one antidepressant drug, (3) studies that mainly focused on ...
The drugs don't work? antidepressants and the current and future
Predictably, given the overwhelming evidence base supporting drug efficacy, the reaction against this paper was strong. McAllister-Williams states that the magnitude of therapeutic difference is the difference between drug and placebo, not absolute response to active drug and thus Kirsch's study in fact supports the idea that antidepressants ...
Pharmacological treatment of depression: A systematic review ...
Depression affects over 300 million individuals worldwide and is responsible for most of the 800,000 annual suicides. Clinical practice guidelines (CPGs) for treatment of depression, founded on scientific evidence, are essential to improve patient care. However, economic and sociocultural factors may influence CPG elaboration, potentially leading to divergences in their recommendations.
The serotonin theory of depression: a systematic umbrella ...
Authors of papers were contacted for clarification when data was missing or unclear. ... on these drugs [67, 68]. As with all research synthesis, the findings of this umbrella review are dependent ...
Major Depressive Disorder: Advances in Neuroscience Research and
Analysis of Published Papers. In the past decade, the total number of papers on depression published worldwide has increased year by year as shown in Fig. 1A. Searching the Web of Science database, we found a total of 43,863 papers published in the field of depression from 2009 to 2019 (search strategy: TI = (depression$) or ts = ("major depressive disorder$")) and py = (2009-2019), Articles).
Antidepressants for the treatment of adults with major ...
The current study data were reported in articles cited in this paper. References. Herrman H, Patel V, Kieling C, Berk M, Buchweitz C, Cuijpers P, et al. Time for united action on depression: a ...
Antidepressant side effects and their impact on treatment ...
Future research should aim to identify specific side effects that contribute to greater burden of side effect severity and poorer antidepressant treatment outcome. ... Guy W. Factor analysis of ...
Application of antidepressants in depression: A systematic review and
Discussion. In this meta -analysis, we systematically summarize the effectiveness and side effects of different types of antidepressants. For the clinical efficacy and side effects of first-line antidepressants, anti-inflammatory drugs and ketamine, this article covers a comprehensive analysis.
Novel and emerging treatments for major depression
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is one of the leading global public health problems. Although existing available pharmacological treatments can be effective, their onset of action can take up to 6 weeks, side-effects are common, and recovery can require treatment with multiple different agents. Although psychosocial interventions ...
Antidepressant Drug Discovery and Development: Mechanism and Drug
research progresses of candidate drugs, the recent advances in small-molecule drug discovery for the potential treatments of depression, and the drug-like properties of these candidate
Depression
R. McShaneN Engl J Med 2023;389:1333-1334. Depression can become self-perpetuating as occupational, relationship, and social losses accrue. Sustained remission is achieved in less than half of ...
Substance Use Disorders and Addiction: Mechanisms, Trends, and
The numbers for substance use disorders are large, and we need to pay attention to them. Data from the 2018 National Survey on Drug Use and Health suggest that, over the preceding year, 20.3 million people age 12 or older had substance use disorders, and 14.8 million of these cases were attributed to alcohol.When considering other substances, the report estimated that 4.4 million individuals ...
Understanding reasons for drug use amongst young people: a functional
The terms `poly-drug' or `multiple drug' use have been used to describe this behaviour although their exact definitions vary. The term `poly-drug use' is often used to describe the use of two or more drugs during a particular time period (e.g. over the last month or year). This is the definition used within the current paper.
Adolescents and substance abuse: the effects of substance abuse on
Substance abuse during adolescence. The use of substances by youth is described primarily as intermittent or intensive (binge) drinking and characterized by experimentation and expediency (Degenhardt et al., Citation 2016; Morojele & Ramsoomar, Citation 2016; Romo-Avilés et al., Citation 2016).Intermittent or intensive substance use is linked to the adolescent's need for activities that ...
(PDF) Drug Addiction: Current Trends and Management
The current paper highlights the causes of drug abuse, and describes the treatment and prevention of drug abuse and addiction for proper management of the problem. Discover the world's research 25 ...
(PDF) Forms of Drug Abuse and Their Effects
There were s ignificant associations between the duration of taking drugs (p<0.001), the number of taking drugs (p<0.006), and the age of first use of drugs (p<0.019) with depression.
Enzyme-linked immunoassay for simultaneous detection of methyl
Methyl parathion is one of the most widely used and typical organophosphorus pesticides in China, which has the characteristics of high toxicity, high efficiency and broad spectrum persistence. Sibutramine is a non-amphetamine central nervous system depressant, which achieves weight loss by disrupting the re Analytical Methods HOT Articles 2024
Next Generation Research Uses Real-World Data to Identify Most
More than 100 million U.S. adults have been diagnosed with hypertension, one of the leading risk factors for cardiovascular disease.While more than 70% of people with hypertension cannot achieve adequate blood pressure control with just one drug, current guidelines only make recommendations for first-line therapy.
A Review of Novel Antidepressants: A Guide for Clinicians
Abstract. This review article aims to provide insight into the mechanisms of action, pharmacokinetics, clinical efficacy, safety and tolerability of four novel antidepressants including desvenlafaxine, vortioxetine, vilazodone, and levomilnacipran. Following keywords are used in PubMed and Scopus to search for relevant articles: (depression ...
Research shows GLP-1 drugs are effective but complex
Research shows GLP-1 receptor agonist drugs are effective but come with complex concerns. May 30, 2024. Drugs like Ozempic, Wegovy and Mounjaro have been around for years, but they've recently been making headlines due to a rise in popularity as weight loss agents. They all belong to a class of drugs known as glucagon-like peptide-1 receptor ...
A new molecular target for antidepressants
Cell Research 31 , 489-490 ( 2021) Cite this article. The mode of action of drugs used to treat depression has long remained mysterious. A new study now shows that unexpectedly, this diverse ...
Research Evaluates Effectiveness, Support for Medicinal Mushrooms
Galloway, N.J. — Psilocybin has been shown to effectively reduce depression and anxiety and a slim majority of New Jersey residents approve legalizing this type of treatment, according to research released today by the William J. Hughes Center for Public Policy at Stockton University. Psilocybin is the psychoactive compound in magic mushrooms.
Existing drug shows promise as treatment for rare genetic disorder
FULL STORY. A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1 ...
New data being presented at ASCO on the long-approved Pfizer drug Lorbrena are remarkable: The daily pill decreased disease progression in non-small cell lung cancer by 81% over five years. That ...
Micromachines
Magnetic soft microrobots have a wide range of applications in targeted drug therapy, cell manipulation, and other aspects. Currently, the research on magnetic soft microrobots is still in the exploratory stage, and most of the research focuses on a single helical structure, which has limited space to perform drug-carrying tasks efficiently and cannot satisfy specific medical goals in terms of ...
Scientists identify mechanism behind drug resistance in malaria
In a paper titled "tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum", published in the journal Nature Microbiology, researchers from SMART's Antimicrobial Resistance (AMR) interdisciplinary research group documented their discovery: A change in a single tRNA, a small RNA molecule that is involved in translating genetic information from RNA to ...
Lung cancer treatment: Pfizer's Lorbrena extends life in some non-small
Cavallini James / Getty Images. Pfizer's lung cancer drug Lorbrena can extend life for patients with a rare form of the disease for years longer than other drugs, according to new research ...
Driver held in death of 1-year-old Lynnwood child struck by SUV
A 1-year-old child playing outside their home in Lynnwood was fatally struck by a man suspected of driving under the influence of drugs Thursday evening, court records show. The 45-year-old driver ...
IMAGES
VIDEO
COMMENTS
Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning. Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning. Pharmacotherapy, especially selective serotonin reuptake ...
Our lack of knowledge cannot be put down to a scarcity of research in existing treatments. In the past decades, more than 500 randomised trials have examined the effects of antidepressant medications, and more than 600 trials have examined the effects of psychotherapies for depression (although comparatively few are conducted for early-onset depression).
2.2.1. Inclusion Criteria . Inclusion criteria are the following: (1) literatures of varying methodologies such as observational, cross-sectional, and retrospective studies, survey, and case reports, (2) studies conducted on all patients aged ≥18 years with a primary diagnosis of depression and prescription of at least one antidepressant drug, (3) studies that mainly focused on ...
Predictably, given the overwhelming evidence base supporting drug efficacy, the reaction against this paper was strong. McAllister-Williams states that the magnitude of therapeutic difference is the difference between drug and placebo, not absolute response to active drug and thus Kirsch's study in fact supports the idea that antidepressants ...
Depression affects over 300 million individuals worldwide and is responsible for most of the 800,000 annual suicides. Clinical practice guidelines (CPGs) for treatment of depression, founded on scientific evidence, are essential to improve patient care. However, economic and sociocultural factors may influence CPG elaboration, potentially leading to divergences in their recommendations.
Authors of papers were contacted for clarification when data was missing or unclear. ... on these drugs [67, 68]. As with all research synthesis, the findings of this umbrella review are dependent ...
Analysis of Published Papers. In the past decade, the total number of papers on depression published worldwide has increased year by year as shown in Fig. 1A. Searching the Web of Science database, we found a total of 43,863 papers published in the field of depression from 2009 to 2019 (search strategy: TI = (depression$) or ts = ("major depressive disorder$")) and py = (2009-2019), Articles).
The current study data were reported in articles cited in this paper. References. Herrman H, Patel V, Kieling C, Berk M, Buchweitz C, Cuijpers P, et al. Time for united action on depression: a ...
Future research should aim to identify specific side effects that contribute to greater burden of side effect severity and poorer antidepressant treatment outcome. ... Guy W. Factor analysis of ...
Discussion. In this meta -analysis, we systematically summarize the effectiveness and side effects of different types of antidepressants. For the clinical efficacy and side effects of first-line antidepressants, anti-inflammatory drugs and ketamine, this article covers a comprehensive analysis.
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is one of the leading global public health problems. Although existing available pharmacological treatments can be effective, their onset of action can take up to 6 weeks, side-effects are common, and recovery can require treatment with multiple different agents. Although psychosocial interventions ...
research progresses of candidate drugs, the recent advances in small-molecule drug discovery for the potential treatments of depression, and the drug-like properties of these candidate
R. McShaneN Engl J Med 2023;389:1333-1334. Depression can become self-perpetuating as occupational, relationship, and social losses accrue. Sustained remission is achieved in less than half of ...
The numbers for substance use disorders are large, and we need to pay attention to them. Data from the 2018 National Survey on Drug Use and Health suggest that, over the preceding year, 20.3 million people age 12 or older had substance use disorders, and 14.8 million of these cases were attributed to alcohol.When considering other substances, the report estimated that 4.4 million individuals ...
The terms `poly-drug' or `multiple drug' use have been used to describe this behaviour although their exact definitions vary. The term `poly-drug use' is often used to describe the use of two or more drugs during a particular time period (e.g. over the last month or year). This is the definition used within the current paper.
Substance abuse during adolescence. The use of substances by youth is described primarily as intermittent or intensive (binge) drinking and characterized by experimentation and expediency (Degenhardt et al., Citation 2016; Morojele & Ramsoomar, Citation 2016; Romo-Avilés et al., Citation 2016).Intermittent or intensive substance use is linked to the adolescent's need for activities that ...
The current paper highlights the causes of drug abuse, and describes the treatment and prevention of drug abuse and addiction for proper management of the problem. Discover the world's research 25 ...
There were s ignificant associations between the duration of taking drugs (p<0.001), the number of taking drugs (p<0.006), and the age of first use of drugs (p<0.019) with depression.
Methyl parathion is one of the most widely used and typical organophosphorus pesticides in China, which has the characteristics of high toxicity, high efficiency and broad spectrum persistence. Sibutramine is a non-amphetamine central nervous system depressant, which achieves weight loss by disrupting the re Analytical Methods HOT Articles 2024
More than 100 million U.S. adults have been diagnosed with hypertension, one of the leading risk factors for cardiovascular disease.While more than 70% of people with hypertension cannot achieve adequate blood pressure control with just one drug, current guidelines only make recommendations for first-line therapy.
Abstract. This review article aims to provide insight into the mechanisms of action, pharmacokinetics, clinical efficacy, safety and tolerability of four novel antidepressants including desvenlafaxine, vortioxetine, vilazodone, and levomilnacipran. Following keywords are used in PubMed and Scopus to search for relevant articles: (depression ...
Research shows GLP-1 receptor agonist drugs are effective but come with complex concerns. May 30, 2024. Drugs like Ozempic, Wegovy and Mounjaro have been around for years, but they've recently been making headlines due to a rise in popularity as weight loss agents. They all belong to a class of drugs known as glucagon-like peptide-1 receptor ...
Cell Research 31 , 489-490 ( 2021) Cite this article. The mode of action of drugs used to treat depression has long remained mysterious. A new study now shows that unexpectedly, this diverse ...
Galloway, N.J. — Psilocybin has been shown to effectively reduce depression and anxiety and a slim majority of New Jersey residents approve legalizing this type of treatment, according to research released today by the William J. Hughes Center for Public Policy at Stockton University. Psilocybin is the psychoactive compound in magic mushrooms.
FULL STORY. A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1 ...
New data being presented at ASCO on the long-approved Pfizer drug Lorbrena are remarkable: The daily pill decreased disease progression in non-small cell lung cancer by 81% over five years. That ...
Magnetic soft microrobots have a wide range of applications in targeted drug therapy, cell manipulation, and other aspects. Currently, the research on magnetic soft microrobots is still in the exploratory stage, and most of the research focuses on a single helical structure, which has limited space to perform drug-carrying tasks efficiently and cannot satisfy specific medical goals in terms of ...
In a paper titled "tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum", published in the journal Nature Microbiology, researchers from SMART's Antimicrobial Resistance (AMR) interdisciplinary research group documented their discovery: A change in a single tRNA, a small RNA molecule that is involved in translating genetic information from RNA to ...
Cavallini James / Getty Images. Pfizer's lung cancer drug Lorbrena can extend life for patients with a rare form of the disease for years longer than other drugs, according to new research ...
A 1-year-old child playing outside their home in Lynnwood was fatally struck by a man suspected of driving under the influence of drugs Thursday evening, court records show. The 45-year-old driver ...